Morphine versus methadone in the pain treatment of advanced-cancer patients followed up at home.

作者: S Mercadante , A Casuccio , A Agnello , R Serretta , L Calderone

DOI: 10.1200/JCO.1998.16.11.3656

关键词:

摘要: PURPOSEThe aim of this study was to evaluate the analgesic and adverse effects doses methadone in comparison morphine.PATIENTS AND METHODSA prospective randomized performed a sample 40 patients with advanced cancer who required strong opioids for their pain management. Patients were treated sustained-release morphine or titrated against effect administered two three times daily according clinical need. Opioid doses, adjuvant medications, symptoms associated opioid therapy, intensity, mechanisms recorded. The escalation indices percentage (OEI%) milligrams (OEImg) calculated. effective score (EAS) that monitors consumption-pain ratio also calculated at fixed weekly intervals.RESULTSdifferences intensity found. reported values OEI significantly less than those observed morphine. Seven th...

参考文章(34)
V. Ventafridda, A. Sbanotto, E. Spoldi, A. Caraceni, F. De Conno, Cancer Pain Management and Drug Delivery Drug Delivery in Cancer Treatment. pp. 3- 17 ,(1987) , 10.1007/978-3-642-73077-1_2
F De Conno, L Groff, C Brunelli, E Zecca, V Ventafridda, C Ripamonti, Clinical experience with oral methadone administration in the treatment of pain in 196 advanced cancer patients. Journal of Clinical Oncology. ,vol. 14, pp. 2836- 2842 ,(1996) , 10.1200/JCO.1996.14.10.2836
Gérard G. Mignault, Jean Latreille, Francis Viguié, Pierre Richer, Francois Lemire, Zoltan Harsanyi, John H. Stewart, Control of cancer-related pain with MS contin®: A comparison between 12-hourly and 8-hourly administration Journal of Pain and Symptom Management. ,vol. 10, pp. 416- 422 ,(1995) , 10.1016/0885-3924(95)00063-5
E. BRUERA, P. LAWLOR, Cancer pain management Acta Anaesthesiologica Scandinavica. ,vol. 41, pp. 146- 153 ,(1997) , 10.1111/J.1399-6576.1997.TB04629.X
S. Mercadante, Methadone in cancer pain European Journal of Pain. ,vol. 1, pp. 77- 83 ,(1997) , 10.1016/S1090-3801(97)90064-1
R.G. TWYCROSS, A comparison of diamorphine-with-cocaine and methadone. British Journal of Clinical Pharmacology. ,vol. 4, pp. 691- 693 ,(1977) , 10.1111/J.1365-2125.1977.TB00433.X
Robin Fainsinger, Teresa Schoeller, Eduardo Bruera, Methadone in the management of cancer pain: a review Pain. ,vol. 52, pp. 137- 147 ,(1993) , 10.1016/0304-3959(93)90125-9