作者: S Mercadante , A Casuccio , A Agnello , R Serretta , L Calderone
DOI: 10.1200/JCO.1998.16.11.3656
关键词:
摘要: PURPOSEThe aim of this study was to evaluate the analgesic and adverse effects doses methadone in comparison morphine.PATIENTS AND METHODSA prospective randomized performed a sample 40 patients with advanced cancer who required strong opioids for their pain management. Patients were treated sustained-release morphine or titrated against effect administered two three times daily according clinical need. Opioid doses, adjuvant medications, symptoms associated opioid therapy, intensity, mechanisms recorded. The escalation indices percentage (OEI%) milligrams (OEImg) calculated. effective score (EAS) that monitors consumption-pain ratio also calculated at fixed weekly intervals.RESULTSdifferences intensity found. reported values OEI significantly less than those observed morphine. Seven th...