Ochrasperfloroid, an ochratoxin–ergosteroid heterodimer with inhibition of IL-6 and NO production from Aspergillus flocculosus 16D-1
作者： Bin-Bin Gu , Fu-Rong Jiao , Wei Wu , Lei Liu , Wei-Hua Jiao
DOI: 10.1039/C8RA10539A
关键词:
摘要: A novel ochratoxin–ergosteroid heterodimer, ochrasperfloroid (1), together with a known mycotoxin, ochratoxin (2), were isolated from the sponge-derived fungus Aspergillus flocculosus 16D-1. The structure of 1 was determined on basis 1D/2D NMR, HRESIMS/MS, and LC-UV/MS analysis its alkaline hydrolyzates, quantum-chemical 13C NMR calculation, comparison literature data. Of note, ergosteroid embedded in is also new structure. Ochrasperfloroid (1) showed potent inhibitory activity towards IL-6 production lipopolysaccharide (LPS)-induced THP-1 cell line, an IC50 value 2.02 μM, NO LPS-activated RAW264.7 macrophages, 1.11 μM.
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