Vasoactive intestinal polypeptide and the nervous system: immunohistochemical evidence for localization in central and peripheral neurons, particularly intracortical neurons of the cerebral cortex.

作者: K. Fuxe , T. Hökfelt , S.I. Said , V. Mutt

DOI: 10.1016/0304-3940(77)90073-8

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摘要: Immunohistochemical studies on rat brain revealed large numbers of vasoactive intestinal polypeptide (VIP)-positive nerve cell bodies all over the limbic cortex and neocortex. Large terminal plexus' were found within layers cortex, but mainly II-IV Thus, association neurons probably exist in cerebral which store VIP or VIP-like peptides, making possible a role for such peptides higher nervous processes. A neuroendocrine function may also be postulated view presence VIP-positive terminals central amygdaloid nucleus, suprachiasmatic medial preoptic nucleus anterior hypothalamic nucleus.

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