Atorvastatin reduction of intravascular thrombosis, increase in cerebral microvascular patency and integrity, and enhancement of spatial learning in rats subjected to traumatic brain injury.

摘要: Object. Atorvastatin, a β-hydroxy-β-methylglutaryl coenzyme A reductase inhibitor, has pleiotropic effects, such as promoting angiogenesis, increasing fibrinolysis, and reducing inflammatory responses, shown promise in enhancing recovery animals with traumatic brain injury (TBI) stroke. The authors tested the effect of atorvastatin on vascular changes after TBI. Methods. Male Wistar rats subjected to controlled cortical impact were perfused at different time points fluorescein isothiocyanate (FITC)—conjugated dextran 1 minute before being killed. Spatial memory function had been measured using Morris Water Maze test various temporal profile intravascular thrombosis was tissue sections by microcomputer imaging device laser confocal microscopy. study revealed following results. 1) Vessels lesion boundary zone hippocampal CA3 region showed variety damage, morphologi...