To Kill But Not Be Killed: Controlling the Activity of Mammalian Pore-Forming Proteins.

摘要: Pore-forming proteins (PFPs) are present in all domains of life, and play an important role host-pathogen warfare the elimination cancers. They can be employed to deliver specific effectors across membranes, disrupt membrane integrity interfering with cell homeostasis, lyse membranes either destroying intracellular organelles or entire cells. Considering destructive potential PFPs, it is perhaps not surprising that mechanisms controlling their activity remarkably complex, especially multicellular organisms. Mammalian PFPs discovered date include complement attack complex (MAC), perforins, as well gasdermins. While primary function perforin-1 gasdermins eliminate infected cancerous host cells, perforin-2 MAC target pathogens directly. Yet, mammalian principle capable generating pores healthy cells which-if uncontrolled-could have dire, potentially lethal consequences. In this review, we will highlight strategies protect from destruction by endogenous while enabling timely efficient