Effective Integration of Targeted Tumor Imaging and Therapy Using Functionalized InP QDs with VEGFR2 Monoclonal Antibody and miR-92a Inhibitor

摘要: Rapid diagnosis and targeted drug treatment require agents that possess multiple functions. Nanomaterials facilitate optical imaging direct delivery have shown great promise for effective cancer treatment. In this study, we first modified near-infrared fluorescent indium phosphide quantum dots (InP QDs) with a vascular endothelial growth factor receptor 2 (VEGFR2) monoclonal antibody to afford function. Then, miR-92a inhibitor, an antisense microRNA enhances the expression of tumor suppressor p63, was attached VEGFR2–InP QDs via electrostatic interactions. The functionalized InP nanocomposite (IMAN) selectively targets sites allows infrared in vivo. We further explored mechanism active targeting. IMAN endocytosed delivered form microvesicles VEGFR2–CD63 signaling. Moreover, induced apoptosis human myelogenous leukemia cells through p63 pathway vitro These results i...