Distinct pattern of human Vdelta1 gammadelta T cells recognizing MICA.

摘要: Gammadelta T cells represent one unique recognition pattern, the limited recognition, which distinguishes from specific for alphabeta and pattern macrophages. Vdelta1 gammadelta cell is major subset of human cells, predominates in mucosal tissue including intestinal epithelia. Presently, a few antigens that Vdelta1TCR can recognize have been identified. Among them, MHC class I chain-related molecules A (MICA) studied most intensively. Besides Vdelta1TCR, MICA also ligand NKG2D, C-type lectin-like activating immunoreceptor. In human, only simultaneously express both types receptors while NK alphabetaT other subsets likewise NKG2D. Although precise mechanisms are still enigmatic, this distinct recognizing predicts biological significance immune defense. Recent years, some progresses made issue. review we summarize related reports put forward novel views based on our group's studies.