Falsely elevated urinary Gb3 (globotriaosylceramide, CTH, GL3).
作者： Sabrina Forni , Xiaowei Fu , Raphael Schiffmann , Lawrence Sweetman
DOI: 10.1016/J.YMGME.2009.01.011
关键词:
摘要: and C17-Gb3 as internal standards. Ten microliters are injected into a UPLC-MS/MS for the simultaneous determination of creatinine Gb3. Urine 100 healthy subjects from newborns to 65 years old was analyzed. The concentration in urine varied widely due diet or age: less then 1 lmol/mL infants some adults higher than 30 adults. Gb3 is usually expressed Gb3/creatinine because believed correct excretion more concentrated [4]. Low (<4 lmol/mL) led falsely elevated ratio Gb3/creatinine, especially (but not exclusively) samples young children (Fig. 1). High lowers Gb3/creatinine. latter problematic case individuals with moderately Gb3, such heterozygote females. lg/ mL urine, does correlate amount
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