Heritability of non-HLA genetics in coeliac disease: a population-based study in 107 000 twins

摘要: Background and objective Almost 100% individuals with coeliac disease (CD) are carriers of the human leucocyte antigen (HLA) DQ2/DQ8 alleles. Earlier studies have, however, failed to consider HLA system when estimating heritability in CD, thus violating an underlying assumption analysis. We examined CD a large population-based sample twins, considering HLA. Design In population-representative 107 912 we identified (equal villous atrophy) through biopsy reports from all Swedish pathology departments. calculated concordance rates tetrachoric correlations for monozygotic (MZ) dizygotic (DZ) twin pairs. Further, estimated first strictly observed data, then non-HLA heritability, representing genetic factors except locus, using approach that circumvent violation assumptions. Results 513 twins diagnosis (prevalence 0.48%). Concordance were higher MZ pairs (0.49) than DZ (0.10), as (0.89 vs 0.51 pairs). The was 75% (95% CI 55% 96%). slightly attenuated, 68% 40% 96%), shared (17%) non-shared (15%) environmental explaining remaining variability CD. Conclusions is characterised by high but our study also suggests may be importance development. seems have only moderate impact on estimates.