Ablation of hypoxic tumors with dose-equivalent photothermal, but not photodynamic, therapy using a nanostructured porphyrin assembly.

摘要: Tumor hypoxia is increasingly being recognized as a characteristic feature of solid tumors and significantly complicates many treatments based on radio-, chemo-, phototherapies. While photodynamic therapy (PDT) photosensitizer interactions with diffused oxygen, photothermal (PTT) has emerged new phototherapy that predicted to be independent oxygen levels within tumors. It been challenging meaningfully compare these two modalities due differences in contrast agents irradiation parameters, no comparative vivo studies have performed until now. Here, by making use recently developed nanostructured self-quenched porphysome nanoparticles, we were able directly PDT PTT using matched light doses porphyrin (with the effective for either or existence nanostructure not). Therefore, demonstrated nanostructure-driven conversion from singlet oxy...