Pentoxifylline Inhibits the Irradiation Induced G2/M Block and Alters DNA Synthesis in P53 Mutant and Repair Deficient Cells
作者： L. Böhm , T. Theron , A. Binder
DOI: 10.1007/978-94-011-4585-5_39
关键词:
摘要: The G1/S and G2/M transitions have been recognised as important checkpoints in the response of cells to sublethal damage. It is commonly thought that delays G1 or G2 progression which typically occurs 10-18 hrs postirradion are protective mechanisms prevent propagation defective DNA. However, this view may be simplistic at variance with fact rejoining DNA strand breaks complete within 3-4 postirradiation.
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