Lysophospholipid Receptors, as Novel Conditional Danger Receptors and Homeostatic Receptors Modulate Inflammation—Novel Paradigm and Therapeutic Potential

摘要: There are limitations in the current classification of danger-associated molecular patterns (DAMP) receptors. To overcome these limitations, we propose a new paradigm by using endogenous metabolites lysophospholipids (LPLs) as prototype. By utilizing data mining method pioneered, made following findings: (1) such LPLs at basal level have physiological functions; (2) under sterile inflammation, expression some is elevated. These act conditional DAMPs or anti-inflammatory homeostasis-associated pattern molecules (HAMPs) for regulating progression inflammation inhibition respectively; (3) receptors and HAMPs differentially expressed human mouse tissues; (4) complex signaling mechanism exists between pro-inflammatory mediators classical that regulate HAMPs. This novel insight will facilitate identification HAMPs, thus promote development therapeutic targets to treat inflammatory disorders.