How myosin organization of the actin cytoskeleton contributes to the cancer phenotype

摘要: The human genome contains 39 genes that encode myosin heavy chains, classified on the basis of their sequence similarity into 12 classes. Most cells express at least different genes, from 8 classes, which are typically composed several class 1 one 2 gene and classes 5, 6, 9, 10, 18 19. Although isoforms all have specific non-overlapping roles in cell, combination they contribute to organization actin cytoskeleton, shape phenotype cell. Over (or under) expression these can strong effects organization, cell cancer as discussed this review.