PD-1 gene rs10204525 and rs7421861 polymorphisms are associated with increased risk and clinical features of esophageal cancer in a Chinese Han population.

摘要: Programmed death-1 (PD-1) polymorphisms have been associated with esophageal cancer risk. Here, the aims of this case-control study were to explore whether three PD-1 (rs10204525, rs7421861, and rs36084323) related risk clinical features in Chinese Han subjects (n = 814 cases 961 controls). We found that rs10204525 but not rs36084323, conferred increased susceptibility cancer. Subgroup analysis revealed all loci among men, rs7421861 correlated patients ≥ 60 years old. The higher TNM stage, was distant metastasis. combination smoking either or genotype an cancer, which is indicative potential gene-environment interactions. gene protein levels, Kaplan-Meier survival curves showed expression poorer overall survival. These data indicate confer individuals.