Novel vaccines against multiple subtypes of influenza virus
作者： Dominick Laddy , David B. Weiner , Jian Yan , Ruxandra Draghia-Akli
DOI:
关键词:
摘要: An aspect of the present invention is directed towards DNA plasmid vaccines capable generating in a mammal an immune response against plurality influenza virus subtypes, comprising and pharmaceutically acceptable excipient. The expressing consensus antigen cell quantity effective to elicit mammal, wherein comprises hemagglutinin (HA), neuraminidase (NA), matrix protein, nucleoprotein, M2 ectodomain-nucleo-protein (M2e-NP), or combination thereof. Preferably HA, NA, M2e-NP, promoter operably linked coding sequence that encodes antigen. Additionally, includes methods eliciting subtypes using provided.
lens.org 参考文章(31)
Thomas R. Jones, Cells transformed or transfected with HCMV US2 gene ,(1998)
Lada Rasochova, Jamie P. Phelps, Jason M. Radam, Nghiep Dang, Recombinant flu vaccines ,(2006)
Peter Ilyinskii, Alexander Shneider, Galini Thoidis, Influenza vaccine compositions and methods of use thereof ,(2006)
Philippe Buchy, Malik Peiris, Jean-Michel Garcia, Ralf Altmeyer, Isabelle Nefkens, Influenza h5 pseudotyped lentiviruses and uses thereof ,(2007)
Dominick J Laddy, David B Weiner, Jian Yan, Ruxandra Draghia-Akli, Vaccines against multiple subtypes of influenza virus ,(2008)
Qi Dang, Richard Schwartz, Methods of Producing Influenza Vaccine Compositions ,(2004)
Wing-Pui Kong, Zhi-Yong Yang, Gary J. Nabel, Terrence Tumpey, Antiviral agents and vaccines against influenza ,(2007)
Shixia Wang, Shan Lu, Influenza nucleic acids, polypeptides, and uses thereof ,(2006)
Ruxandra Draghia-Akli, Robert J. Schwartz, Synthetic muscle promoters with activities exceeding naturally occurring regulatory sequences in cardiac cells ,(2003)
Ruxandra Draghia-Akli, Amir S. Khan, Electroporation devices and methods of using same for electroporation of cells in mammals ,(2007)