Role of Resveratrol in Transmitochondrial AMD RPE Cells.
作者： Sonali Nashine , Anthony B. Nesburn , Baruch D. Kuppermann , Maria Cristina Kenney
DOI: 10.3390/NU12010159
关键词:
摘要: Resveratrol is a phytoalexin, stilbenoid compound with antioxidant properties attributable to its bioactive trans-resveratrol content. This study characterized the effects of over-the-counter (OTC) resveratrol nutritional supplements and HPLC-purified formulation, in human transmitochondrial age-related macular degeneration (AMD) retinal pigment epithelial (RPE) patient cell lines. These lines, which were created by fusing blood platelets obtained from dry wet AMD patients mitochondria-deficient (Rho0) ARPE-19 cells, had identical nuclei (derived cells) but different mitochondria that derived patients. After treatment, levels viability reactive oxygen species production measured. Results demonstrated treatment formulations improved decreased generation each line. Although further studies are required establish cytoprotective potential under physiological conditions, this novel established positive OTC cybrid lines vitro.
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