MiR-511 mimic transfection inhibits the proliferation, invasion of osteosarcoma cells and reduces metastatic osteosarcoma tumor burden in nude mice via targeting MAPK1.

摘要: Osteosarcoma, a highly aggressive cancer, can rapidly metastasize to distant organs such as lung, liver, brain. Despite much progress in the therapeutic regime has been made, prognosis of osteosarcoma remains poor. In present study, microRNA-511 (miR-511) is lowly expressed cells, including MG63, U-2 OS, Saos-2 while mitogen activated protein kinase1 (MAPK1) cells. Interestingly, MAPK1 might be target miR-511. We found that overexpression miR-511 by mimic transfection may result low expression MAPK1. Further study showed inhibits development MG63 cell, proliferation and invasion. Moreover, reduces metastatic tumor burden nude mice. These activities are mediated targeting Our provides new sight for molecular pathogenesis osteosarcoma.