Advanced drug delivery to the lymphatic system: lipid-based nanoformulations

摘要: The delivery of drugs and bioactive compounds via the lymphatic system is complex dependent on physiological uniqueness system. route plays an important role in transporting extracellular fluid to maintain homeostasis transferring immune cells injury sites, able avoid first-pass metabolism, thus acting as a bypass for with lower bioavailability, ie, those undergoing more hepatic metabolism. also provides option therapeutic molecules, such treat cancer human immunodeficiency virus, which can travel through Lymphatic imaging useful evaluating disease states treatment plans progressive diseases lymph Novel lipid-based nanoformulations, solid lipid nanoparticles nanostructured carriers, have unique characteristics that make them promising candidates delivery. These formulations are superior colloidal carrier systems because they controlled release properties provide better chemical stability drug molecules. However, multiple factors regulate drugs. Prior uptake, nanoformulations required undergo interstitial hindrance modulates Therefore, uptake distribution by depends particle size, surface charge, molecular weight, hydrophobicity. Types concentration emulsifier affecting All these cause changes intermolecular interactions between nanoparticle matrix incorporated drug, turn affects into Two been administered routes (subcutaneous, pulmonary, intestinal) targeting This paper detailed review novel their different routes, well vivo vitro models used study transport Physicochemical influence advantages discussed.