Early wheezing phenotypes and severity of respiratory illness in very early childhood: study on intrauterine exposure to fine particle matter.

摘要: The main goal of the paper was to assess pattern risk factors having an impact on onset early wheezing phenotypes in birth cohort 468 two-year olds and investigate severity respiratory illness relation both phenotypes, environmental tobacco smoke (ETS) personal PM(2.5) exposure over pregnancy period (fine particulate matter). secondary possible association persistent with length baby at birth. Pregnant women were recruited from ambulatory prenatal clinics first second trimester pregnancy. Only 18-35 years age, who claimed be non-smokers, singleton pregnancies, without illicit drug use HIV infection, free chronic diseases eligible for study. In statistical analysis health children multinomial logistic regression zero-inflated Poisson models used. Approximately one third study sample experienced 2 life about two cases (67%) symptom developed already year life. easily reversible 70% infants receded adjusted relative ratio (RRR) increased maternal atopy (RRR=3.05; 95%CI: 1.30-7.15), older siblings 1.67-5.58) ETS (RRR=1.13; 1.04-1.23), but inversely associated (RRR=0.88; 0.76-1.01). incidence ratios (IRR) coughing, difficult breathing, runny/stuffy nose pharyngitis/tonsillitis wheezers much higher than that observed among non-wheezers significantly depended exposure, atopy. shows a clear inverse between age or education illnesses calls more research efforts aiming explanation hidden behind proxy measures quality care babies. data support hypothesis burden symptoms childhood possibly later may programmed when system is completing its growth maturation.