Le syndrome de Lynch et l'instabilité des microsatellites : revue de littérature.

摘要: Microsatellite instability (MSI) phenotype occurs in approximately 15 to 24% of colorectal cancer (CRC) patients and may be sporadic or hereditary. It reflects a mutator the tumor due lack mismatch repair system. MSI is indeed one characteristics CRCs occurring Lynch syndrome some cases. with have better prognosis than microsatellite stability (MSS). This explained partly by more important anti-tumor immune response apoptosis cells which mutations accumulate. However, retrospective studies, stage II was associated no benefit even deleterious effect 5-FU alone based adjuvant therapy. Nevertheless, results obtained III FOLFOX type chemotherapy remain favorable studies.