An enantioselective solutions towards synthesizing “skip” 1,3 dimethyl stereocenters. A synthesis of 4S(2E,4R∗,6R∗)-4,6-Dimethyl-2-octenoic acid
作者： Richard H. Schlessinger , Kevin W. Gillman
DOI: 10.1016/0040-4039(96)00015-9
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摘要: Abstract A versatile method of synthesizing “skip” 1,3 dimethyl stereocenters via an enantioselective aldol reaction followed by stereoselective catalytic hydrogenation produces three syn contiguous chiral centers. Barton deoxygenation the intermediary hydroxyl group provides desired skip array.
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