The analgesic activity and possible mechanisms of deacetyl asperulosidic acid methyl ester from Ji shi teng in mice.
作者： Yu-feng Chen , Jing-yi Zhang , Ming-hong Zhao , Ming Yan , Qing-chun Zhao
DOI: 10.1016/J.PBB.2012.07.005
关键词:
摘要: Deacetyl Asperulosidic Acid Methyl Ester (DAAME) from Ji shi teng was evaluated on analgesic activity in mice using chemical and thermal models of nociception. Given intraperitoneally, DAAME, at doses 40 80 mg/kg, produced significant inhibitions nociception induced by intraperitoneal acetic acid, subplantar formalin/capsaicin injections the tail-flick test hot plate test. In open-field rotarod test, DAAME couldn't impair motor performance, indicating that observed antinociception unlikely due to abnormality. a measurement core body temperature, (80 mg/kg) did not affect temperature within min. Moreover, DAAME-induced capsaicin significantly antagonized glibenclamide. The results suggested DAAME-produced possibly involved ATP sensitive K+ channels which merited exploring further.
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