PEPT-1, Peptide Transporter 1
作者： Isabel Rubio-Aliaga , Hannelore Daniel
DOI: 10.1016/B978-008055232-3.60475-1
关键词:
摘要: The peptide transporter PEPT-1 belongs to the proton-coupled oligopeptide family. contains most likely 12 transmembrane domains with amino- and carboxy-termini in cytosol. carrier protein is responsible for electrogenic proton-dependent uphill transport of dipeptides tripeptides related drugs. driven by three forces, proton gradient, membrane potential, substrate gradient. substrates are selected peptidomimetics, stereoselective. Peptidomimetic that transported include beta-lactam antibiotics ACE-inhibitors, designed prodrugs, nonpeptidic compounds such as delta-aminolevulinic acid. predominantly expressed apical mature epithelial cells small intestine. There a species orthologue, …
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