Paroxysmal discharges in the EL mouse, a genetic model of epilepsy

摘要: The EL/Suz (EL) mouse is a strain that highly susceptible to convulsive seizures after repeated sensory stimulation. Its control strain, DDY/Jc1 (DDY), less under similar conditions. seizure prone phenotype the result of differences at several genetic loci. In vivo electrical recordings from EL brain have shown appearance abnormal discharges in hippocampus are critical onset generalized seizures, indicating plays an important role activity. present study, electrophysiological between and DDY mice (9-15 weeks age) were examined by comparing field potentials recorded dentate granule cell layer hippocampal slices had not been stimulated induce seizures. physiological solution, no significant observed characteristics perforant path evoked or paired pulse depression using 20 300 ms interstimulus intervals. After 60 min disinhibition following bicuculline (10 microM) exposure, however, prolonged large amplitude potentials, paroxysmal discharges, stimulation gyrus but absent strain. Paroxysmal curtailed APV responses temporal lobe epileptic patients. response hilar was identical both strains composed single population spike before exposure. Mossy fiber terminals molecular either We propose mechanisms leading greater likelihood discharge generation may be development and/or this phenotypic difference its parent