Disparities in rate, triggers, and management in pediatric and adult cases of suspected drug‐induced anaphylaxis in Canada

摘要: Introduction Data is sparse on drug-induced anaphylaxis (DIA) and there have not been studies assessing the differences in clinical characteristics management of DIA between adults children. Objective We assessed percentage, diagnosis, among all visits three pediatric one adult emergency departments (ED) across Canada. Methods Children presenting to Montreal Children's Hospital (MCH), British Columbia (BCCH), at London Health Sciences Center Hopital du Sacre-Coeur with were recruited as part Cross-Canada Anaphylaxis Registry. A standardized data form documenting reaction was completed patients followed annually determine assessment by allergist use confirmatory tests. Results From June 2012 May 2016, 51 children from centers 64 center anaphyalxis. More than half cases prospectively recruited. The percentage similar but higher Montreal. Most reactions triggered non-antibiotic drugs, adults, antibiotics. majority a third did see an after initial reaction. In those that allergist, diagnosis established either skin test or oral challenge less 20% cases. Conclusions Our results reveal disparities rate, culprit, versus adults. Further, most suspected drug allergy are appropriately diagnosed. Guidelines improve required.