Optimal Serum 25-Hydroxyvitamin D Levels for Multiple Health Outcomes

作者: Heike A. Bischoff-Ferrari

DOI: 10.1007/978-0-387-77574-6_5

关键词:

摘要: Recent evidence suggests that higher vitamin D intakes beyond current recommendations may be associated with better health outcomes. In this chapter, is summarized from different studies evaluate threshold levels for serum 25(OH)D in relation to bone mineral density (BMD), lower extremity function, dental health, risk of falls, admission nursing home, fractures, cancer prevention and incident hypertension. For all endpoints, the most advantageous appeared at least 75 nmol/l (30 ng/ml) prevention, desirable are between 90-120 (36-48 ng/ml). An intake no less than 1000 IU (25 mcg) D3 (cholecalciferol) per day adults bring 50% population up nmol/l. Thus, doses needed individuals into desired range. While estimates suggest 2000 successfully safely achieve goal, implications or total adult need addressed future studies.

参考文章(150)
O. H. Sørensen, BI. Lund, B. Saltin, BJ. Lund, R. B. Andersen, L. Hjorth, F. Melsen, L. Mosekilde, Myopathy in bone loss of ageing: improvement by treatment with 1 alpha-hydroxycholecalciferol and calcium. Clinical Science. ,vol. 56, pp. 157- 161 ,(1979) , 10.1042/CS0560157
Roger Bouillon, Terry Moody, Michael Sporn, J. Carl Barrett, Anthony W. Norman, NIH deltanoids meeting on Vitamin D and cancer. Conclusion and strategic options. The Journal of Steroid Biochemistry and Molecular Biology. ,vol. 97, pp. 3- 5 ,(2005) , 10.1016/J.JSBMB.2005.06.016
Laurent Dukas, Heike A. Bischoff, Lyn S. Lindpaintner, Erich Schacht, Dagmar Birkner-binder, Thomas N. Damm, Beat Thalmann, Hannes B. Stähelin, Alfacalcidol reduces the number of fallers in a community-dwelling elderly population with a minimum calcium intake of more than 500 mg daily. Journal of the American Geriatrics Society. ,vol. 52, pp. 230- 236 ,(2004) , 10.1111/J.1532-5415.2004.52060.X
R U Simpson, G A Thomas, A J Arnold, Identification of 1,25-dihydroxyvitamin D3 receptors and activities in muscle. Journal of Biological Chemistry. ,vol. 260, pp. 8882- 8891 ,(1985) , 10.1016/S0021-9258(17)39433-4
Kerry E. Broe, Tai C. Chen, Janice Weinberg, Heike A. Bischoff-Ferrari, Michael F. Holick, Douglas P. Kiel, A Higher Dose of Vitamin D Reduces the Risk of Falls in Nursing Home Residents: A Randomized, Multiple‐Dose Study Journal of the American Geriatrics Society. ,vol. 55, pp. 234- 239 ,(2007) , 10.1111/J.1532-5415.2007.01048.X
Ellen D. Burgess, Ralph G. Hawkins, Mamoru Watanabe, Interaction of 1,25-dihydroxyvitamin D and plasma renin activity in high renin essential hypertension. American Journal of Hypertension. ,vol. 3, pp. 903- 905 ,(1990) , 10.1093/AJH/3.12.903