Modulatory role of neuropeptide FF system in nociception and opiate analgesia.
作者： Hsiu-Ying T. Yang , Tao Tao , Michael J. Iadarola
DOI: 10.1016/J.NPEP.2007.06.004
关键词:
摘要: Abstract The tetra-peptide FMRF-NH 2 is a cardioexcitatory peptide in the clam. Using antibody against this peptide, -like immunoreactive material was detected mammalian CNS. Subsequently, peptides were isolated from bovine brain and characterized to be FLFQPQRF-NH (NPFF) AGEGLSSPFWSLAAPQRF-NH (NPAF). genes encoding NPFF precursor proteins receptors 1 are expressed all vertebrate species examined date highly conserved. Among many biological roles suggested for system, possible modulatory role of nocicetion opiate analgesia has been most widely investigated. Pharmacologically, NPFF-related found exhibit also potentiate analgesic activity opiates when administered intrathecally but attenuate induced intracerebroventricularly. RF-NH including delay rate acid sensing ion channels (ASIC) desensitization resulting enhancing gated currents, raising possibility that may have pain through ASIC. as well NPFF-R2, preferred receptor NPFF, unevenly rat CNS with highest levels localized superficial layers dorsal spinal cord. These two present root ganglia (DRG), though at low normal rats. NPFF-R2 mRNAs coordinately up-regulated cord DRG rats peripheral inflammation. In addition, immunoreactivity primary afferents increased by findings early studies on morphine modulating activities modulation further supported distribution its regulation system vivo .
core.ac.uk
elsevier.com
sci-hub.se 参考文章(106)
Tomohiro Osugi, Kazuyoshi Ukena, Stacia A. Sower, Hiroshi Kawauchi, Kazuyoshi Tsutsui, Evolutionary origin and divergence of PQRFamide peptides and LPXRFamide peptides in the RFamide peptide family: Insights from novel lamprey RFamide peptides FEBS Journal. ,vol. 273, pp. 1731- 1743 ,(2006) , 10.1111/J.1742-4658.2006.05187.X
Nicolas Voilley, Jan de Weille, Julien Mamet, Michel Lazdunski, Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors The Journal of Neuroscience. ,vol. 21, pp. 8026- 8033 ,(2001) , 10.1523/JNEUROSCI.21-20-08026.2001
Shuji Hinuma, Yasushi Shintani, Shoji Fukusumi, Norio Iijima, Yoshio Matsumoto, Masaki Hosoya, Ryo Fujii, Takuya Watanabe, Kuniko Kikuchi, Yasuko Terao, Takahiko Yano, Takanori Yamamoto, Yuji Kawamata, Yugo Habata, Mari Asada, Chieko Kitada, Tsutomu Kurokawa, Haruo Onda, Osamu Nishimura, Masaki Tanaka, Yasuhiko Ibata, Masahiko Fujino, New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals. Nature Cell Biology. ,vol. 2, pp. 703- 708 ,(2000) , 10.1038/35036326
Graham J. Dockray, The expanding family of -RFamide peptides and their effects on feeding behaviour. Experimental Physiology. ,vol. 89, pp. 229- 235 ,(2004) , 10.1113/EXPPHYSIOL.2004.027169
Elisabeth Bonnard, Odile Burlet-Schiltz, Bernard Monsarrat, Jean-Philippe Girard, Jean-Marie Zajac, Identification of proNeuropeptide FFA peptides processed in neuronal and non-neuronal cells and in nervous tissue. FEBS Journal. ,vol. 270, pp. 4187- 4199 ,(2003) , 10.1046/J.1432-1033.2003.03816.X
Minna-Liisa Änkö, Pertti Panula, Functional modulation of human delta opioid receptor by neuropeptide FF BMC Neuroscience. ,vol. 6, pp. 21- 21 ,(2005) , 10.1186/1471-2202-6-21
Tetsuya Ohtaki, Yasushi Shintani, Susumu Honda, Hirokazu Matsumoto, Akira Hori, Kimiko Kanehashi, Yasuko Terao, Satoshi Kumano, Yoshihiro Takatsu, Yasushi Masuda, Yoshihiro Ishibashi, Takuya Watanabe, Mari Asada, Takao Yamada, Masato Suenaga, Chieko Kitada, Satoshi Usuki, Tsutomu Kurokawa, Haruo Onda, Osamu Nishimura, Masahiko Fujino, Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. Nature. ,vol. 411, pp. 613- 617 ,(2001) , 10.1038/35079135
Johanna M. Nystedt, Annika M. Brandt, Jami Mandelin, Ferdinand S. Vilim, Edward B. Ziff, Pertti Panula, Analysis of human neuropeptide FF gene expression. Journal of Neurochemistry. ,vol. 82, pp. 1330- 1342 ,(2002) , 10.1046/J.1471-4159.2002.01035.X
Kazuyoshi Ukena, Kazuyoshi Tsutsui, Distribution of novel RFamide-related peptide-like immunoreactivity in the mouse central nervous system Neuroscience Letters. ,vol. 300, pp. 153- 156 ,(2001) , 10.1016/S0304-3940(01)01583-X
Jinghui Xie, Margaret P. Price, John A. Wemmie, Candice C. Askwith, Michael J. Welsh, ASIC3 and ASIC1 mediate FMRFamide-related peptide enhancement of H+-gated currents in cultured dorsal root ganglion neurons. Journal of Neurophysiology. ,vol. 89, pp. 2459- 2465 ,(2003) , 10.1152/JN.00707.2002