Third generation cephalosporin-resistant gram-negative bacilli in the feces of hospitalized children.

摘要: In view of the widespread use third generation cephalosporins in hospitalized infants, we attempted to determine whether their was associated with emergence resistance fecal Gram-negative bacilli. Stools from infants for varying durations were cultured on MacConkey agar containing 4 micrograms/ml cefotaxime. All isolates growing this medium identified and susceptibilities 29 antimicrobial agents determined. Sixty-five studied whom 44 receiving a cephalosporin, 7 another antibiotic 14 no antibiotic. Thirty-one strains resistant (minimal inhibitory concentrations > or = 16 micrograms/ml) cefotaxime, ceftriaxone ceftazidine) isolated 26 infants. The proportions not significantly different they were: (1) cephalosporin not; (2) longer shorter than 2 days (3) older younger 3 months not. Notably 8 harbored within 24 hours admission. commonest belonged genera Enterobacter (10), Citrobacter (6), Serratia (3), Cedecea Chromobacterium (3). conclusion had high incidence colonization bacilli cephalosporins. These bacteria predominantly those known produce broad spectrum beta-lactamases. This necessarily infant such antibiotics prolonged hospitalization.