Frequency of the Bcl-2/IgH Rearrangement in Normal Individuals: Implications for the Monitoring of Disease in Patients With Follicular Lymphoma
作者： Karin E. Summers , Lindsey K. Goff , A. Gerry Wilson , Rajnish K. Gupta , T. Andrew Lister
DOI: 10.1200/JCO.2001.19.2.420
关键词:
摘要: PURPOSE: To determine the incidence and frequency of Bcl-2/IgH rearrangement in peripheral blood normal individuals to define potential complication this may pose for molecular monitoring disease patients with follicular lymphoma (FL). MATERIALS AND METHODS: The major breakpoint cluster region DNA extracted from or lymphoblastoid cell lines 481 was determined using a TaqMan real-time polymerase chain reaction assay (PE Applied Biosystems, Foster City, CA). RESULTS: Twenty three percent samples were positive rearrangement, approximately 3% these at levels more than 1 104 cells. CONCLUSION: presence circulating Bcl-2/IgH+ cells, other those derived malignant clone, could confound detection quantitation minimal residual FL, particularly low tumor burden.
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