Basic FGF-induced activation of telomerase in rheumatoid synoviocytes.
作者： H. Tsumuki , T. Hasunuma , T. Kobata , T. Kato , A. Uchida
关键词:
摘要: To investigate the mechanism of persistent proliferation rheumatoid arthritis (RA) synoviocytes in situ, we examined activity telomerase enzyme and expression related factors cultured synoviocytes. Cultured obtained from patients with (n = 29), osteoarthritis (OA, n 18), traumatic joint disease (TJD, 4) were examined. Telomerase was detected by TRAP (telomeric repeat amplification protocol) assay, 12 out 29 samples (41%) RA showed a positive activity, whereas none OA TJD this activity. Results confirmed PCR-ELISA. The enhanced basic fibroblast growth factor (bFGF). mRNA factors, such as hTERC, TRF2, TEP-1, no difference between Our results suggest that is activated synoviocytes, bFGF upregulates
springer.com
sci-hub.se 参考文章(20)
Elisabeth A. Seftor, Gary S. Firestein, Karlfried R. Aupperle, Miguel Barbosa, David L. Boyle, Mary Hendrix, Nathan J. Zvaifler, Regulation of synoviocyte proliferation, apoptosis, and invasion by the p53 tumor suppressor gene. American Journal of Pathology. ,vol. 152, pp. 1091- 1098 ,(1998)
G Kingsley, G S Panayi, Joint destruction in rheumatoid arthritis: biological bases. Clinical and Experimental Rheumatology. ,vol. 15, ,(1997)
D. Kalden-Nemeth, J. Grebmeier, F. Wolf, C. Antoni, B. Manger, J. R. Kalden, NMR monitoring of rheumatoid arthritis patients receiving anti-TNF-α monoclonal antibody therapy Rheumatology International. ,vol. 16, pp. 249- 255 ,(1997) , 10.1007/BF01375657
Edward D. Harris, Pathogenesis of rheumatoid arthritis The American Journal of Medicine. ,vol. 80, pp. 4- 10 ,(1986) , 10.1016/0002-9343(86)90072-0
G S Panayi, T-cell-dependent pathways in rheumatoid arthritis Current Opinion in Rheumatology. ,vol. 9, pp. 236- 240 ,(1997) , 10.1097/00002281-199705000-00010
N. Kim, M. Piatyszek, K. Prowse, C. Harley, M. West, P. Ho, G. Coviello, W. Wright, S. Weinrich, J. Shay, Specific association of human telomerase activity with immortal cells and cancer Science. ,vol. 266, pp. 2011- 2015 ,(1994) , 10.1126/SCIENCE.7605428
Jerry W. Shay, Telomerase in human development and cancer Journal of Cellular Physiology. ,vol. 173, pp. 266- 270 ,(1997) , 10.1002/(SICI)1097-4652(199711)173:2<266::AID-JCP33>3.0.CO;2-B
Gregg B. Morin, The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats Cell. ,vol. 59, pp. 521- 529 ,(1989) , 10.1016/0092-8674(89)90035-4
Susan Smith, Titia de Lange, TRF1, a mammalian telomeric protein. Trends in Genetics. ,vol. 13, pp. 21- 26 ,(1997) , 10.1016/S0168-9525(96)10052-4
Junli Feng, Walter D Funk, Sy-Shi Wang, Scott L Weinrich, Ariel A Avilion, Choy-Pik Chiu, Robert R Adams, Edwin Chang, Richard C Allsopp, Jinghua Yu, Siyuan Le, Michael D West, Calvin B Harley, William H Andrews, Carol W Greider, Bryant Villeponteau, The RNA component of human telomerase Science. ,vol. 269, pp. 1236- 1241 ,(1995) , 10.1126/SCIENCE.7544491