Prolotherapy Injections, Saline Injections, and Exercises for Chronic Low-Back Pain: A Randomized Trial

摘要: Objectives. To assess the efficacy of a prolotherapy injection and exercise protocol in treatment chronic nonspecific low back pain. Design. Randomized controlled trial with two- by- two factorial design, triple- blinded for status, single- status. Setting. General practice. Participants. One hundred ten participants low- pain average 14 years duration were randomized to have repeated ( 20% glucose/ 0.2% lignocaine) or normal saline injections into tender lumbo- pelvic ligaments perform either flexion/ extension exercises activity over 6 months. Main outcome measures: Pain intensity VAS) disability scores Roland- Morris) at 2.5, 4, 6, 12, 24 Results. Follow- up was achieved 96% 12 months 80% 2 years. Ligament injections, activity, resulted significant sustained reductions throughout trial, but no attributable effect found activity. At months, proportions achieving more than 50% reduction from baseline by group glucose- lignocaine: 0.46 versus saline: 0.36. By these exercise: 0.41 activity: 0.39. Corresponding > 0.42 0.36 0.38. There between differences any above measures. Conclusions. In pain, occur ligament irrespective solution injected concurrent use exercises.