The Intramolecular Mannich and Related Reactions

摘要: Cyclization reactions of iminium ions, R12CNR2+, are a recurring theme in the assembly cyclic nitrogenous compounds by both chemists and Nature.1 The electron-deficient ion is nitrogen analog an α-alkoxycarbenium (oxonium) or activated carbonyl group as such fundamental electrophilic component CC bond formation. Although it common practice synthesis to modify reactivity simple ions introducing electron-withdrawing electron-donating groups (Figure 1), only cyclization parent species will be covered this chapter. important N-acyliminium examined separately (see Volume 2, Chapter 4.5).