Hypothalamic-pituitary-adrenal axis modulation of GABAergic neuroactive steroids influences ethanol sensitivity and drinking behavior.
作者： Kathleen A. Grant , Kevin N. Boyd , A. Leslie Morrow , Patrizia Porcu
DOI:
关键词:
摘要: Activation of the hypothalamic-pituitary-adrenal (HPA) axis leads to elevations in γ-aminobutyric acid (GABA)-ergic neuroactive steroids that enhance GABA neurotransmission and restore homeostasis following stress. This regulation HPA maintains healthy brain function protects against neuropsychiatrie disease. Ethanol sensitivity is influenced by GABAergic effects ethanol, mayprevent excessive drinking rodents humans. Low ethanol associated with greater alcohol consumption increased risk ofalcoholism. Indeed, ethanol-dependent rats show blunted neurosteroid responses administration may contribute tolerance propensity drink amounts ethanol. The review presents evidence support hypothesis neurosteroids actions prevent drinking, while lack underlie innate or chronic drinking. Neurosteroids have therapeutic use withdrawal for relapse prevention.
elsevier.com参考文章(129)
Giovanni Biggio, Robert H Purdy, None, Neurosteroids and brain function Tokyo : Academic Press. ,(2001)
ALI IRANMANESH, JOHANNES D. VELDHUIS, MICHAEL L. JOHNSON, GERMAN LIZARRALDE, 24‐Hour Pulsatile and Orcadian Patterns of Cortisol Secretion in Alcoholic Men Journal of Andrology. ,vol. 10, pp. 54- 63 ,(1989) , 10.1002/J.1939-4640.1989.TB00062.X
A. Leslie Morrow, Margaret J. VanDoren, Leslie L. Devaud, Effects of progesterone or neuroactive steroid Nature. ,vol. 395, pp. 652- 652 ,(1998) , 10.1038/27106
Juan Carlos Jorge-Rivera, Kerry L. McIntyre, Leslie P. Henderson, Anabolic Steroids Induce Region- and Subunit-Specific Rapid Modulation of GABAA Receptor-Mediated Currents in the Rat Forebrain Journal of Neurophysiology. ,vol. 83, pp. 3299- 3309 ,(2000) , 10.1152/JN.2000.83.6.3299
Bernard J. Carroll, A Specific Laboratory Test for the Diagnosis of Melancholia Archives of General Psychiatry. ,vol. 38, pp. 15- 22 ,(1981) , 10.1001/ARCHPSYC.1981.01780260017001
N L Harrison, J L Barker, J W Harrington, M D Majewska, Structure-activity relationships for steroid interaction with the gamma-aminobutyric acidA receptor complex. Journal of Pharmacology and Experimental Therapeutics. ,vol. 241, pp. 346- 353 ,(1987)
Margaret J. VanDoren, Douglas B. Matthews, Gregory C. Janis, A. Chistina Grobin, Leslie L. Devaud, A. Leslie Morrow, Neuroactive Steroid 3α-Hydroxy-5α-Pregnan-20-One Modulates Electrophysiological and Behavioral Actions of Ethanol The Journal of Neuroscience. ,vol. 20, pp. 1982- 1989 ,(2000) , 10.1523/JNEUROSCI.20-05-01982.2000
Soon Lee, E. Donne Schmidt, Fred J. H. Tilders, Catherine Rivier, Effect of Repeated Exposure to Alcohol on the Response of the Hypothalamic-Pituitary-Adrenal Axis of the Rat: I. Role of Changes in Hypothalamic Neuronal Activity Alcoholism: Clinical and Experimental Research. ,vol. 25, pp. 98- 105 ,(2001) , 10.1111/J.1530-0277.2001.TB02132.X
W. Hundt, U. Zimmermann, M. Pottig, K. Spring, F. Holsboer, The combined dexamethasone-suppression/CRH-stimulation test in alcoholics during and after acute withdrawal. Alcoholism: Clinical and Experimental Research. ,vol. 25, pp. 687- 691 ,(2001) , 10.1111/J.1530-0277.2001.TB02268.X
G. Gatti, P. Bertello, L. Gurioli, G. Pinna, A. Berruti, A. G. De Micheli, A. Angeli, Plasma testosterone, estradiol, progesterone and 17-hydroxy-progesterone responses to single-dose stimulation with human chorionic gonadotropin in chronic male alcoholics. Journal of Endocrinological Investigation. ,vol. 8, pp. 313- 319 ,(1985) , 10.1007/BF03348503