Skeletal Manifestations in NF1

摘要: Neurofibromatosis type 1 (NF1) is a multisystem disorder that includes skeletal abnormalities. Although tumors and pigmentary findings are hallmark features of NF1, the orthopedic manifestations can lead to diagnosis require modified approaches management. One NIH clinical diagnostic criteria for NF1 group distinctive osseous lesions, providing reference unique aspect in this condition (Stumpf et al., Arch Neurol 45:575–578, 1988; Gutmann JAMA 278:51–57, 1997, book). In addition sphenoid wing dysplasia tibial bowing with long bone dysplasia, health care providers familiar aware many associated guide them both establishing level confidence steer These additional myriad include scoliosis, dystrophic non-dystrophic forms, short stature, pectus abnormalities, cranial osteopenia, vertebral body dural ectasia, non-ossifying fibromas, central giant cell granulomas.