Sequence of developmental alterations following acute ethanol exposure in mice: craniofacial features of the fetal alcohol syndrome.

摘要: The typical facial features of the fetal alcohol syndrome (FAS) were induced in C57B1/6J mice with acute maternal ethanol administration at gastrulation stages embryonic development. These include microcephaly, microphthalmia, short palpebral fissures, deficiencies philtral region, and a long upper lip. Scanning electron microscopy (SEM) analysis embryos 24 hours following initial exposure 7 days 0 gestation revealed an obvious size reduction neural plate, which was particularly noticeable forebrain region. As expected, plate development these early result abnormal brain eye formation. SEM later closely set olfactory placodes resultant medial nasal prominences (that area responsible for forming region lip, alveolar ridge contained incisors, anterior portion hard palate--the primary palate). Cleared skeletal preparations affected newborns had marked premaxillary bone deficiencies. One most prevalent known human teratogens has major malformation-inducing effect on gastrulating embryos, developmental stage present prior to pregnancy recognition by women.