Paroxysmal dyskinesias in mice
作者： Thomas L. Shirley , Lekha M. Rao , Ellen J. Hess , H. A. Jinnah
DOI: 10.1002/MDS.21829
关键词:
摘要: Animal models of human disease are important tools for revealing the underlying mechanisms pathophysiology and developing therapeutic strategies. Several unique mouse calcium channel mutants have been identified with nonepileptic, episodic dyskinetic movements that phenotypically similar to paroxysmal dyskinesias. In this report, video demonstrations these motor attacks provided two previously described mutants, tottering lethargic, as well a new one, rocker. Semiquantitative comparisons using different rating scales reveal differences in attack morphology, severity, duration among strains. These mice provide three independent dyskinesia support prior proposals channelopathies may underlie disorders.
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