Sex Differences in T Cells in Hypertension

摘要: Abstract Purpose Hypertension is a major risk factor for cardiovascular disease, stroke, and end-organ damage. There sex difference in blood pressure (BP) that begins adolescence continues into adulthood, which men have higher prevalence of hypertension compared with women until the sixth decade life. Less than 50% hypertensive adults United States manage to control their BP recommended levels using current therapeutic options, are more likely uncontrolled high BP. This, despite facts aware they seek treatment disease. Novel targets need be identified both sexes increase percentage individuals controlled The purpose this article was review available literature on role T cells sexes, potential application/implications targeting immune hypertension. Methods A search PubMed conducted determine impact cell–mediated terms included sex, gender, estrogen, testosterone, inflammation, cells, regulatory Th17 hypertension, . Additional data were from our laboratory examinations cytokine expression kidneys male female spontaneously rats (SHRs) differential gene renal cortex mesenteric arterial bed SHRs. Findings growing scientific base regarding pathogenesis control; however, majority these studies been performed exclusively males, fact develop increasing evidence although also mediate females, there distinct differences T-cell profile functional health, work needed better define relative different subtypes sexes. Implications challenge now fully understand molecular mechanisms by system regulates how components interact so specific can targeted therapeutically without compromising natural defenses.