The epidemiology of fungal infections in patients with hematologic malignancies: the SEIFEM-2004 study.
作者： Luana Fianchi , Annamaria Nosari , Lorella Melillo , Rosa Fanci , Anna Candoni
DOI: 10.3324/%X
关键词:
摘要: BACKGROUND AND OBJECTIVES: The aim of this study was to evaluate the incidence and outcome invasive fungal infections (IFI) in patients with hematologic malignancies. DESIGN METHODS: This a retrospective cohort admitted between 1999 2003 18 hematology wards Italy. Each participating center provided information on all newly diagnosed malignancies during survery period episodes IFI experienced by these patients. RESULTS: formed 11,802 malignacies: acute leukemia (myeloid 3012, lymphoid 1173), chronic 596, 1104), lymphoma (Hodgkin's 844, non-Hodgkin's 3457), or multiple myeloma (1616). There were 538 proven probable (4.6%); 373 (69%) occurred myeloid leukemia. Over half (346/538) caused molds (2.9%), most cases Aspergillus spp. (310/346). 192 yeast (1.6%) included 175 candidemia. Overall IFI-attributable mortality rates 2% (209/11802) 39% (209/538), respectively. highest associated zygomycosis (64%) followed fusariosis (53%), aspergillosis (42%), candidemia (33%). INTERPRETATION CONCLUSIONS: Patients are currently at higher risk than yeasts, is among spp still common pathogens, Candida Other agents rare. attributable rate for has dropped from 60-70% approximately 40%. Candidemia-related remains within 30-40% range reported literature although decreased.
haematologica.org
elsevier.com
sci-hub.st 参考文章(42)
M E Tosti, A Nosari, A Candoni, B Allione, L Pagano, C Girmenia, Gimema Infection Program, D D'Antonio, L Corvatta, L Mele, P Martino, M Montillo, A Tonso, A Chierichini, M Buelli, M Picardi, A Del Favero, C Savignano, A Cenacchi, A Bonini, L Melillo, Gruppo Italiano Malattie Ematologiche dell'Adulto, P Ricci, L Cudillo, Infections caused by filamentous fungi in patients with hematologic malignancies. A report of 391 cases by GIMEMA Infection Program. Haematologica. ,vol. 86, pp. 862- 870 ,(2001) , 10.3324/%X
Livio Pagano, Massimo Offidani, Luana Fianchi, Annamaria Nosari, Anna Candoni, Marco Picardi, Laura Corvatta, Domenico D'Antonio, Corrado Girmenia, Pietro Martino, Albano Del Favero, GIMEMA (Gruppo Italiano Malattie EMatologiche dell'Adulto) Infection Program, None, Mucormycosis in hematologic patients. Haematologica. ,vol. 89, pp. 207- 214 ,(2004) , 10.3324/%X
Corrado Girmenia, Livio Pagano, Laura Corvatta, Luca Mele, Albano Del Favero, Pietro Martino for the Gimema Infection Pr, The epidemiology of fusariosis in patients with haematological diseases. British Journal of Haematology. ,vol. 111, pp. 272- 276 ,(2000) , 10.1046/J.1365-2141.2000.02312.X
K Mühlemann, C Wenger, R Zenhäusern, M G Täuber, Risk factors for invasive aspergillosis in neutropenic patients with hematologic malignancies. Leukemia. ,vol. 19, pp. 545- 550 ,(2005) , 10.1038/SJ.LEU.2403674
M. Nucci, N. Spector, A. P. Bueno, C. Solza, T. Perecmanis, P. C. Bacha, W. Pulcheri, Risk Factors and Attributable Mortality Associated with Superinfections in Neutropenic Patients with Cancer Clinical Infectious Diseases. ,vol. 24, pp. 575- 579 ,(1997) , 10.1093/CLIND/24.4.575
Galit P Rosen, Karin Nielsen, Sungching Glenn, Jon Abelson, Jaime Deville, Theodore B Moore, Invasive fungal infections in pediatric oncology patients: 11-year experience at a single institution. Journal of Pediatric Hematology Oncology. ,vol. 27, pp. 135- 140 ,(2005) , 10.1097/01.MPH.0000155861.38641.CA
Masahiro Kami, Utako Machida, Katsuko Okuzumi, Tomoko Matsumura, Shin-ichiro Mori, Akiko Hori, Takeshi Kashima, Yoshinobu Kanda, Yoichi Takaue, Hisashi Sakamaki, Hisamaru Hirai, Akiko Yoneyama, Yoshitomo Mutou, Effect of fluconazole prophylaxis on fungal blood cultures: an autopsy-based study involving 720 patients with haematological malignancy British Journal of Haematology. ,vol. 117, pp. 40- 46 ,(2002) , 10.1046/J.1365-2141.2002.03414.X
M. Hong Nguyen, James E. Peacock, Arthur J. Morris, David C. Tanner, Minh Ly Nguyen, David R. Snydman, Marilyn M. Wagener, Michael G. Rinaldi, Victor L. Yu, The changing face of candidemia: emergence of non-Candida albicans species and antifungal resistance The American Journal of Medicine. ,vol. 100, pp. 617- 623 ,(1996) , 10.1016/S0002-9343(95)00010-0
Livio Pagano, Luana Fianchi, Luca Mele, Corrado Girmenia, Massimo Offidani, Paolo Ricci, Maria E. Mitra, Marco Picardi, Cecilia Caramatti, Paolo Piccaluga, Annamaria Nosari, Massimo Buelli, Bernardino Allione, Agostino Cortelezzi, Francesco Fabbiano, Giuseppe Milone, Rosangela Invernizzi, Bruno Martino, Luciano Masini, Giuseppe Todeschini, Maria A. Cappucci, Domenico Russo, Laura Corvatta, Pietro Martino, Albano Del Favero, Pneumocystis carinii pneumonia in patients with malignant haematological diseases: 10 years' experience of infection in GIMEMA centres British Journal of Haematology. ,vol. 117, pp. 379- 386 ,(2002) , 10.1046/J.1365-2141.2002.03419.X
Jorge Mora-Duarte, Robert Betts, Coleman Rotstein, Arnaldo Lopes Colombo, Luis Thompson-Moya, Juanita Smietana, Robert Lupinacci, Carole Sable, Nicholas Kartsonis, John Perfect, Comparison of caspofungin and amphotericin B for invasive candidiasis. The New England Journal of Medicine. ,vol. 347, pp. 2020- 2029 ,(2002) , 10.1056/NEJMOA021585