Drug-induced immune hemolytic anemia: the last 30 years of changes.

摘要: Drug-induced immune hemolytic anemia (DIIHA) is a rare condition that occurs primarily as result of drug-induced antibodies, either drug-dependent or drug-independent. Drug- dependent antibodies can be detected by testing drug-treated red blood cells (RBCs) untreated RBCs in the presence solution drug. Drug-independent react with (no drug added) and cannot distinguished from warm autoantibodies. Many changes have occurred during last 30 years, such which drugs most commonly cause DIIHA, optimal methods for identifying them, theories behind mechanisms they react. This article reviews major DIIHA since early 1980s involving complex mechanism, cephalosporins, nonimmunologic protein adsorption, penicillins. Because serologic results associated mimic those expected autoimmune transfusion reactions, may go undetected some cases.