Effects of Oxide Layer Composition and Radial Compression on Nickel Release in Nitinol Stents

摘要: There is a public health need to understand the effects of surface layer thickness and composition on corrosion in nickel-containing medical devices. To address this knowledge gap, five groups Nitinol stents were manufactured by various processing methods that altered titanium oxide layer. The following surfaces created: >3500 nm thick mixed thermal (OT), ~420 nm (SP), ~130 nm (AF), ~4 nm native (MP), an passivated (EP). Radially compressed not devices evaluated for nickel (Ni) ion release 60-day immersion test. results indicated OT released most Ni, followed SP AF groups. For stents, which exhibited thickest layers, radial compression significantly increased Ni when compared non-compressed stents. This result was observed AF, MP, indicating may be explained cracking thicker layers during crimping. Strong correlations between cumulative release. These findings elucidate importance uniform laser-cut