The importance of Ras in drug resistance in cancer.

摘要: In this review, we analyse the impact of oncogenic Ras mutations in mediating cancer drug resistance, and progress made abrogation through pharmacological targeting. At a physiological level, is implicated many cellular proliferation survival pathways. However, within small GTPase can be responsible for initiation cancer, therapeutic resistance failure ultimately disease relapse. Often termed 'undruggable', notoriously difficult to target directly, due its structure intrinsic activity. Thus, Ras-mediated remains considerable problem. with advances both analytical techniques novel classes, landscape against changing. Allele-specific, direct Ras-targeting agents have reached clinical trials first time, indicating there may, at last, hope targeting such an elusive but significant protein better more effective therapy.