Decline in the need for blood transfusions in cancer patients due to the use of epoietin alfa during cisplatin based chemotherapy

摘要: OBJECTIVE To compare the need for blood transfusions between two groups of patients treated with cisplatin-containing chemotherapy. One these received epoetin alpha therapy. DESIGN Prospective an historical control group. METHODS From April 1998 to December 1999, 44 who were being cisplatin and gemcitabine also administered (10,000 U subcutaneously, thrice weekly) from onset anaemia. The red cell in this group was compared a 46 same combination chemotherapy regimen November 1995 July 1997. RESULTS In group, each patient average 1.6 as 0.7 (a 58% reduction). number units cells transfused per 3.6 1.8 50% none more than 2 whereas 10 (22%) 3 or transfusions. patients, therapy had be stopped due occurrence hypertension. CONCLUSION Epoetin reduced during Its toxic effect minimal.