Role of ART in imprinting disorders.

摘要: Assisted reproductive technologies (ART) offer revolutionary infertility treatments for millions of childless couples around the world. Currently, ART accounts 1 to 3% annual births in industrialized countries and continues expand rapidly. Except an increased incidence premature births, these are considered safe. However, new evidence published during past decade has suggested imprinting disorders children conceived by ART. Specifically, risk was reported Beckwith-Wiedemann syndrome (BWS), Angelman (AS), Silver-Russell syndrome, retinoblastoma. In contrast, some studies have found no association between BWS, AS, Prader-Willi transient neonatal diabetes mellitus, The variability protocols rarity complicate determining causative relationship disorders. Nevertheless, compelling experimental data from animal also suggest a link Further comprehensive, appropriately powered needed better address magnitude ART-associated Large longitudinal particularly critical evaluate long-term effects not only perinatal period but into adulthood. An important consideration is determine if implicated actually related procedures or itself.