Methods for decreasing body weight and treating diabetes

摘要: Disclosed herein are methods of treating diabetes (e.g., increasing glucose tolerance, reducing insulin resistance, and decreasing serum lipids) and/or body weight overweight or obesity) including administering a therapeutically effective amount composition an inhibitor hypoxia- inducible factor la (HIF1α) to subject with in need reduction weight. The HIF1α can be administered combination pharmaceutically acceptable carrier. In some examples, the is orally.