Fatigue associated with multiple sclerosis: diagnosis, impact and management.

摘要: In patients with multiple sclerosis (MS) fatigue is the most common symptom and one of disabling features. As many as 40% have described it single symptom--a higher percentage than weakness, spasticity, motor problems, or bowel bladder problems. The etiology pathophysiology MS-related remain unknown. Studies failed to demonstrate an association between level disability, clinical disease subtype, gender, although recent data show depression quality life. Imaging studies using positron emission tomography suggest that in MS related hypometabolism specific brain areas, including frontal subcortical circuits. impact on patient functioning life clearly warrants intervention. addition nonpharmacologic measures, such exercise energy conservation strategies, several pharmacologic agents been evaluated for their ability reduce fatigue, amantadine, central nervous system stimulants (pemoline), novel wake-promoting agent modafinil.