Characterization of COX19, a Widely Distributed Gene Required for Expression of Mitochondrial Cytochrome Oxidase
作者： Marina P. Nobrega , Simone C. B. Bandeira , John Beers , Alexander Tzagoloff
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摘要: COX19, a nuclear gene ofSaccharomyces cerevisiae, was cloned by transformation of respiratory-deficient mutant from complementation group G188 apet collection. The codes for an 11-kDa protein (Cox19p) required expression cytochrome oxidase. Becausecox19 mutants are able to synthesize the mitochondrial and products oxidase, Cox19p probably functions post-translationally during assembly enzyme. is present in cytoplasm mitochondria, where it exists as soluble intermembrane protein. This dual location similar what previously reported Cox17p, low molecular weight copper thought be maturation CuA center subunit 2 similarity their subcellular distribution, combined with presence four cysteines that align subset suggests like latter, may function metal transport mitochondria.
sci-hub.se 参考文章(37)
G. M. Manthey, J. E. McEwen, The product of the nuclear gene PET309 is required for translation of mature mRNA and stability or production of intron-containing RNAs derived from the mitochondrial COX1 locus of Saccharomyces cerevisiae. The EMBO Journal. ,vol. 14, pp. 4031- 4043 ,(1995) , 10.1002/J.1460-2075.1995.TB00074.X
A Tzagoloff, M Nobrega, N Gorman, P Sinclair, On the functions of the yeast COX10 and COX11 gene products. Iubmb Life. ,vol. 31, pp. 593- 598 ,(1993)
B. Séraphin, M. Simon, G. Faye, MSS18, a yeast nuclear gene involved in the splicing of intron aI5 beta of the mitochondrial cox1 transcript. The EMBO Journal. ,vol. 7, pp. 1455- 1464 ,(1988) , 10.1002/J.1460-2075.1988.TB02963.X
Gérard Faye, Chantal Kujawa, Hiroshi Fukuhara, Physical and genetic organization of petite and grande yeast mitochondrial DNA: IV.† In vivo Transcription Products of Mitochondrial DNA and Localization of 23 S Ribosomal RNA in Petite Mutants of Saccharomyces cerevisiae☆ Journal of Molecular Biology. ,vol. 88, pp. 185- 203 ,(1974) , 10.1016/0022-2836(74)90304-0
Jeffrey N. Strathern, James R. Broach, Elizabeth W. Jones, The Molecular biology of the yeast Saccharomyces : metabolism and gene expression Cold Spring Harbor Laboratory. ,(1982)
G Daum, P C Böhni, G Schatz, Import of proteins into mitochondria. Cytochrome b2 and cytochrome c peroxidase are located in the intermembrane space of yeast mitochondria. Journal of Biological Chemistry. ,vol. 257, pp. 13028- 13033 ,(1982) , 10.1016/S0021-9258(18)33617-2
J E McEwen, C Ko, B Kloeckner-Gruissem, R O Poyton, Nuclear functions required for cytochrome c oxidase biogenesis in Saccharomyces cerevisiae. Characterization of mutants in 34 complementation groups. Journal of Biological Chemistry. ,vol. 261, pp. 11872- 11879 ,(1986) , 10.1016/S0021-9258(18)67323-5
A Tzagoloff, A Akai, RB Needleman, Assembly of the mitochondrial membrane system. Characterization of nuclear mutants of Saccharomyces cerevisiae with defects in mitochondrial ATPase and respiratory enzymes. Journal of Biological Chemistry. ,vol. 250, pp. 8228- 8235 ,(1975) , 10.1016/S0021-9258(19)40840-5
Benjamin S. Glick, Liza A. Pon, Isolation of highly purified mitochondria from Saccharomyces cerevisiae. Methods in Enzymology. ,vol. 260, pp. 213- 223 ,(1995) , 10.1016/0076-6879(95)60139-2
Gottfried Schatz, The doors to organelles Nature. ,vol. 395, pp. 439- 440 ,(1998) , 10.1038/26620