HLA-DRB1 genes, rheumatoid factor, and elevated C-reactive protein: independent risk factors of radiographic progression in early rheumatoid arthritis. Berlin Collaborating Rheumatological Study Group.

摘要: Objective. To evaluate the prognostic value of HLA-DRB 1 antigens, rheumatoid factor (RF), and C-reactive protein (CRP) with radiographic outcome arthritis (RA). Methods. In total, 139 patients early RA ( 0, > 5, 10] was compared by methods survival analysis. Results. At 4 years' disease duration, DRB1 * 04 or 01 positive had RS 0 10 (73% 27%, respectively) significantly more frequently than negative (37% 7%, respectively). Nearly independently genetic predisposition, RF elevated CRP at start DMARD treatment were predictive for erosive years. Elevated (≥ 15 mg/l) increased probability in from 64.0% (in 40.9% HLA predisposed CRP. contrast, no case found 43 who neither these 2 risk factors. Conclusion. Our findings support that predisposition plays an important role regard to progression. However, this effect is modified serum concentration activity.