Characterization of the conversion between CD133+ and CD133- cells in colon cancer SW620 cell line.
作者： Jian-Ming Feng , Ze-Hong Miao , Yi Jiang , Yi Chen , Jia-Xin Li
DOI: 10.4161/CBT.22000
关键词:
摘要: The state of cancer stem cells (CSC) under reversible fluctuations, which has been revealed in breast most recently, suggests that subpopulations with distinct phenotypes and functions within can undergo inter-conversion. To investigate the possibility colon cells, we employed CD133 as CSC marker, characterized expression pattern biological features CD133+ CD133- subsets. Flow cytometry was bimodally expressed SW620 among eight cell lines. clonal displayed a differential gene profile, higher cellular reactive oxygen species (ROS), enhanced tumorigenesis resistance to 5-fluorouracil. conversion term phenotype sorted observed vitro vivo. fraction decreased from 99% 80% population while rising 5 10% during first 20-day cultiv...
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