Combined histoarchitectural and cytological biopsy grading improves grading accuracy in low-grade prostate cancer
作者： Burkhard Helpap , Jens Köllermann
DOI: 10.1111/J.1442-2042.2011.02902.X
关键词:
摘要: Objectives: Accurate tumor grading on prostate biopsy represents the mainstay for therapy planning. Biopsy undergrading is a persistent diagnostic dilemma with therapeutic relevance. We questioned whether Gleason combined an established alternative system incorporating cytological parameters improves accuracy. Methods: Needle biopsies of 968 patients and corresponding radical prostatectomy specimens were graded according to system. In addition, all histo- Helpap. grade, as well Gleason/Helpap was compared final score pathological tumor-stage prostatectomy. Results: 6 cancers, upgrading seen in 76.0% (98/129), 30.2% them (39/129) showed non-organ confined disease. 6/Helpap 2a patients, found 22 out 24 (91.7%, P < 0.0001), organ-confined disease (pT2a). 2b just 9 105 (8.6%), rate decreased 62.8% (66/105, P = 0.0001). higher grades, failed show benefit over sole grading. Conclusion: Combined identification low-grade/low-stage cancers might contribute more precise planning cancer management.
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