Sources and Functions of Extracellular Small RNAs in Human Circulation
作者： Joëlle V. Fritz , Anna Heintz-Buschart , Anubrata Ghosal , Linda Wampach , Alton Etheridge
DOI: 10.1146/ANNUREV-NUTR-071715-050711
关键词:
摘要: Various biotypes of endogenous small RNAs (sRNAs) have been detected in human circulation, including microRNAs, transfer RNAs, ribosomal RNA, and yRNA fragments. These extracellular sRNAs (ex-sRNAs) are packaged and secreted by many different cell types. Ex-sRNAs exhibit differences in abundance in several disease states and have, therefore, been proposed for use as effective biomarkers. Furthermore, exosome-borne ex-sRNAs have been reported to elicit physiological responses in acceptor cells. Exogenous ex …
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